Model systems for flavoenzyme activity. Regulation of flavin recognition via modulation of receptor hydrogen-bond donor-acceptor properties

被引：66

作者：

Deans, R

Cooke, G

Rotello, VM

机构：

[1] UNIV MASSACHUSETTS,DEPT CHEM,AMHERST,MA 01003

[2] UNIV E ANGLIA,SCH CHEM SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 04期

关键词：

D O I：

10.1021/jo961877c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have synthesized a new family of receptors for flavins based on 6-aryl-2,4-(acyldiamino)-s-triazines. In these synthetic hosts, systematic variation of the spatially remote substituents on the 6-aryl ring alters the hydrogen-bond-donating abilities of the amide functionality and the hydrogen-bond-accepting properties of the triazine N(3). This variation results in a strong modulation of the efficiency of flavin binding, with association constants for the receptor flavin complexes ranging over an 8-fold range.

引用

页码：836 / 839

页数：4

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