aging;
bioinformatics;
computational biology;
gerontology;
systems biology;
D O I:
10.1016/j.arr.2003.08.006
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
To study human aging is an enormous challenge. The complexity of the aging phenotype and the near impossibility of studying aging directly in humans oblige researchers to resort to models and extrapolations. Computational approaches offer a powerful set of tools to study human aging. In one direction we have data-mining methods, from comparative genomics to DNA microarrays, to retrieve information in large amounts of data. Afterwards, tools from systems biology to reverse engineering algorithms allow researchers to integrate different types of information to increase our knowledge about human aging. Computer methodologies will play a crucial role to reconstruct the genetic network of human aging and the associated regulatory mechanisms. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
机构:
Univ Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA
Marcotte, EM
论文数: 引用数:
h-index:
机构:
Pellegrini, M
Thompson, MJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA
Thompson, MJ
Yeates, TO
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA
Yeates, TO
Eisenberg, D
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA
机构:
Univ Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA
Marcotte, EM
论文数: 引用数:
h-index:
机构:
Pellegrini, M
Thompson, MJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA
Thompson, MJ
Yeates, TO
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA
Yeates, TO
Eisenberg, D
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Inst Mol Biol, US DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA