Antiproliferative role of dopamine: Loss of D-2 receptors causes hormonal dysfunction and pituitary hyperplasia

被引:154
作者
Saiardi, A
Bozzi, Y
Baik, JH
Borrelli, E
机构
[1] Inst. Genet. Biol. Molec. et Cell., CNRS/INSERM/ULP, 67404, C. U. de Strasbourg
[2] Medical Research Center, College of Medicine, Yonsei University, Seoul
关键词
D O I
10.1016/S0896-6273(00)80352-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The function of dopamine (DA) in the nervous system is paralleled by its neuroendocrine control of pituitary gland functions. Here, we document the neuroendocrine function of dopamine by studying the pituitary gland of mice lacking DA D-2 receptors (D2R). These mice present a striking, progressive increase in lactotroph number, which ultimately leads to tumors in aged animals. Females develop tumors much earlier than males. An estrogen-mediated lactotroph proliferation cannot account for this sexual dimorphism, since D2R-null females are hypoestrogenic and, thus, have estrogen levels similar to males. In contrast, prolactin levels are six times higher in females than in males. We show that active prolactin receptors are present in the pituitary and their expression increases in concomitance with tumor expansion. These results point to prolactin as an autocrine proliferative factor in the pituitary gland. Additionally, they demonstrate an antiproliferative function for DA regulated through D-2 receptor activation.
引用
收藏
页码:115 / 126
页数:12
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