Effect of coriander seeds on hexachlorocyclohexane induced lipid peroxidation in rat liver

被引：22

作者：

Anilakumar, KR ^{[1
]}

Nagaraj, NS ^{[1
]}

Santhanam, K ^{[1
]}

机构：

[1] Def Food Res Lab, Biochem & Nutr Discipline, Mysore 570011, Karnataka, India

来源：

NUTRITION RESEARCH | 2001年 / 21卷 / 11期

关键词：

hexachlorocyclohexane; coriander seeds; lipid peroxides; antioxidants; detoxifying enzymes;

D O I：

10.1016/S0271-5317(01)00338-4

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effect of prefeeding of coriander seed powder (CSP) at 10% level on hexachlorocyclohexane (HCH) induced oxidative stress in rat liver was studied. The prefeeding of rats with CSP was found to reduce the HCH-induced rise in conjugated dienes, hydroperoxide and malondialdehyde (MDA) contents in liver. The intra peritonial injection of HCH reduced hepatic superoxide dismutase (SOD), catalase, glutathione S-transferase (GS-t), glucose-6-phosphate dehydrogenase (G-6-PDH) and glutathione reductase (GSSGR) activities in liver, where as the hepatic glutathione peroxidase (GSH-Px) and kidney gamma -glutamyltranspeptidase (GGT) activities were elevated. The prefeeding of CSP per se increased hepatic SOD, catalase, GS-t, G-6-PDH and GSSGR activities as well as in CSP prefed and then HCH-administered rats. The work shows the modulation of hepatic antioxidant system as a result of the prefeeding of CSP, which were otherwise reduced by HCH injection. The results reported here elicit the antioxidative effect of coriander seeds against HCH-induced formation of free radicals in rat liver. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：1455 / 1462

页数：8

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