The evolutionary rate of a protein is influenced by features of the interacting partners

被引：21

作者：

Makino, T

Gojobori, T ^{[1
]}

机构：

[1] Natl Inst Genet, Ctr Informat Biol, Mishima, Shizuoka 411, Japan

[2] Natl Inst Genet, DNA Data Bank Japan, Mishima, Shizuoka 411, Japan

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2006年 / 23卷 / 04期

关键词：

protein-protein interaction; functional module; Saccharomyces cerevisiae; evolution;

D O I：

10.1093/molbev/msj090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rates of protein evolution are thought to be influenced by features of protein-protein interaction (PPI). However, the most important features of interaction for determining the evolutionary rate are poorly understood. Here, we consider four categories for PPIs in Saccharomyces cerevisiae. Properties we consider are the extent to which proteins interact with proteins of the same function or different function (DF) and the extent to which these interactions involve connections in the dense part or sparse part (SP) of a PPI network. Our findings are that proteins with DF-SP interactions evolve at the slowest rate of all the proteins examined.

引用

页码：784 / 789

页数：6

共 25 条

[11] Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins [J].