Synthesis of enantiomerically enriched β-amino alcohol derivatives via asymmetric lithiation of O-benzyl carbamates-imine addition using (-)-sparteine complexes

被引：13

作者：

Arrasate, S ^{[1
]}

Lete, E ^{[1
]}

Sotomayor, N ^{[1
]}

机构：

[1] Univ Basque Country, Fac Ciencias, Dept Quim Organ 2, E-48080 Bilbao, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(02)00078-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The asymmetric lithiation of O-benzyl carbamates-imine addition sequence using sec-butyllithium/(-)-sparteine complexes has been studied. The reactions proceed with high diastereoselectivity, giving the threo beta-amino alcohol derivatives with modest to good e.e. The best enantioinduction was obtained with O-benzyl carbamates bearing methoxy substituents on the aromatic ring. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：311 / 316

页数：6

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