NOD-like and Toll-like receptors or inflammasomes contribute to kidney disease in a canonical and a non-canonical manner

被引：43

作者：

Anders, Hans-Joachim ^{[1
]}

Lech, Maciej ^{[1
]}

机构：

[1] Klinikum Univ Munchen, Div Renal, Med Klin & Poliklin 4, D-80336 Munich, Germany

来源：

KIDNEY INTERNATIONAL | 2013年 / 84卷 / 02期

关键词：

NLRP3; INFLAMMASOME; SIGNALING PATHWAY; RENAL INJURY; IMMUNITY; FIBROSIS; TLR4;

D O I：

10.1038/ki.2013.122

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Tissue remodeling in kidney disease involves sterile inflammation, because tissue necrosis, in acute kidney injury, produces endogenous agonists to innate pattern recognition receptors that trigger innate immunity. In chronic kidney disease, however, a functional role of such pattern recognition receptors is questionable. Here we summarize and discuss the current evidence on a potential contribution of canonical and non-canonical pattern recognition receptor signaling in chronic kidney disease.

引用

页码：225 / 228

页数：4

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