Selection of adenoid cystic carcinoma cell clone highly metastatic to the lung: An experimental study

被引：47

作者：

Guan, XF ^{[1
]}

Qiu, WL ^{[1
]}

He, RG ^{[1
]}

Zhou, XAJA ^{[1
]}

机构：

[1] SHANGHAI MED UNIV 2,DEPT ORAL MAXILLOFACIAL SURG,SHANGHAI 200011,PEOPLES R CHINA

来源：

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 1997年 / 26卷 / 02期

关键词：

adenoid cystic carcinoma; lung metastases; clone; selection; TUMOR-CELLS; NUDE-MICE; MELANOMA;

D O I：

10.1016/S0901-5027(05)80830-6

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Lung metastasis is very common in patients with adenoid cystic carcinoma (ACC), The purpose of the present study is to establish a model for an experimental study of ACC metastatic mechanisms and antimetastatic procedures. After five repeated selections in vivo, combined with an in vitro cloning technique and analysis of platelet aggregation activity, a clone (Acc-M) highly metastatic to the lung was selected from an ACC cell line (Acc-2). The metastatic rate was 96% vs 18% for Acc-M and the Acc-2 cell line. The metastatic rate and the weight of the lung with metastases correlated positively with platelet aggregation activity. The present study might be important for research into mechanisms of ACC metastases.

引用

页码：116 / 119

页数：4

共 21 条

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