Lens biology - development and human cataractogenesis

被引：92

作者：

Francis, PJ

Berry, V

Moore, AT

Bhattacharya, S

机构：

[1] UCL, Dept Mol Genet, Inst Ophthalmol, London EC1V 9EL, England

[2] Moorfields Eye Hosp, London EC1V 2PD, England

[3] Moorfields Eye Hosp, London EV1V 2PD, England

[4] Addenbrookes Hosp, Cambridge CB2 2QQ, England

来源：

TRENDS IN GENETICS | 1999年 / 15卷 / 05期

关键词：

D O I：

10.1016/S0168-9525(99)01738-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cataract, or opacification of the lens of the eye, is the commonest cause of visual impairment world-wide. It is only treatable at present by surgical removal. Recent advances in our understanding of the genetics of human cataract, in particular the inherited congenital form, together with the development of an array of animal models have provided valuable new insights into normal vertebrate lens biology and the mechanisms that underlie cataract formation. In this article, we review the current state of research in these areas and discuss thinking regarding the relationship between the phenotypes observed and the underlying genotype in inherited cataract.

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收藏

页码：191 / 196

页数：6

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