A hierarchical model for evolution of 23S ribosomal RNA

被引:163
作者
Bokov, Konstantin [1 ]
Steinberg, Sergey V. [1 ]
机构
[1] Univ Montreal, Dept Biochim, Montreal, PQ H3C 3J7, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
PEPTIDYL TRANSFERASE CENTER; ANGSTROM RESOLUTION; BOND FORMATION; SUBUNIT; BASE; SITE; ORIGIN;
D O I
10.1038/nature07749
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The emergence of the ribosome constituted a pivotal step in the evolution of life. This event happened nearly four billion years ago, and any traces of early stages of ribosome evolution are generally thought to have completely eroded away. Surprisingly, a detailed analysis of the structure of the modern ribosome reveals a concerted and modular scheme of its early evolution.
引用
收藏
页码:977 / 980
页数:4
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