Squalamine: An Appropriate Strategy against the Emergence of Multidrug Resistant Gram-Negative Bacteria?

被引：48

作者：

Salmi, Chanaz ^{[1
]}

Loncle, Celine ^{[1
]}

Vidal, Nicolas ^{[1
]}

Letourneux, Yves ^{[1
]}

Fantini, Jacques ^{[3
]}

Maresca, Marc ^{[3
]}

Taieb, Nadira ^{[3
]}

Pages, Jean-Marie ^{[1
]}

Brunel, Jean Michel ^{[2
]}

机构：

[1] Fac Med & Pharm, UMR MD1, Marseille, France

[2] Univ Mediterranee, Fac Med, URMITE, UMR 6236, Marseille, France

[3] Univ Paul Cezanne, Fac Sci St Jerome, CRN2M, CNRS UMR 6231, Marseille, France

来源：

PLOS ONE | 2008年 / 3卷 / 07期

关键词：

D O I：

10.1371/journal.pone.0002765

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We reported that squalamine is a membrane-active molecule that targets the membrane integrity as demonstrated by the ATP release and dye entry. In this context, its activity may depend on the membrane lipid composition. This molecule shows a preserved activity against bacterial pathogens presenting a noticeable multi-resistance phenotype against antibiotics such as polymyxin B. In this context and because of its structure, action and its relative insensitivity to efflux resistance mechanisms, we have demonstrated that squalamine appears as an alternate way to combat MDR pathogens and by pass the gap regarding the failure of new active antibacterial molecules.

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