Squalamine: A polyvalent drug of the future?

被引：44

作者：

Brunel, JM ^{[1
]}

Salmi, C ^{[1
]}

Loncle, C ^{[1
]}

Vidal, N ^{[1
]}

Letourneux, Y ^{[1
]}

机构：

[1] Univ Paul Cezanne, IMRN, INRA, Lab SESNAB,Fac St Jerome,UMR 1111, F-13397 Marseille, France

来源：

CURRENT CANCER DRUG TARGETS | 2005年 / 5卷 / 04期

关键词：

squalamine; aminosterol; cancer; age-related macular degeneration (AMD); appetite suppression; weight reduction;

D O I：

10.2174/1568009054064642

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?

引用

页码：267 / 272

页数：6

共 45 条

[1] Appetite suppression and weight reduction by a centrally active aminosterol [J].

Ahima, RS ;

Patel, HR ;

Takahashi, N ;

Qi, Y ;

Hileman, SM ;

Zasloff, MA .

DIABETES, 2002, 51 (07) :2099-2104

[2] Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na+/H+ exchanger isoform NHE3 [J].

Akhter, S ;

Nath, SK ;

Tse, CM ;

Williams, J ;

Zasloff, M ;

Donowitz, M .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 276 (01) :C136-C144

[3] Surveillance of antimicrobial resistance - what, how and whither? [J].

Bax, R ;

Bywater, R ;

Cornaglia, G ;

Goossens, H ;

Hunter, P ;

Isham, V ;

Jarlier, V ;

Jones, R ;

Phillips, I ;

Sahm, D ;

Senn, S ;

Struelens, M ;

Taylor, D ;

White, A .

CLINICAL MICROBIOLOGY AND INFECTION, 2001, 7 (06) :316-325

[4] Vascular development: Cellular and molecular regulation [J].

Beck, L ;

DAmore, PA .

FASEB JOURNAL, 1997, 11 (05) :365-373

[5]

Bhargava P, 2001, CLIN CANCER RES, V7, P3912

[6] ANTIBACTERIAL PEPTIDES - KEY COMPONENTS NEEDED IN IMMUNITY [J].

BOMAN, HG .

CELL, 1991, 65 (02) :205-207

[7] Recent advances in the synthesis of spermine and spermidine analogs of the shark aminosterol squalamine [J].

Brunel, JM ;

Letourneux, Y .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (20) :3897-3907

[8] Molecular mechanisms of blood vessel formation [J].

Bussolino, F ;

Mantovani, A ;

Persico, G .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (07) :251-256

[9] Sharks: A potential source of antiangiogenic factors and tumor treatments [J].

Cho, JJ ;

Kim, YT .

MARINE BIOTECHNOLOGY, 2002, 4 (06) :521-525

[10] Squalamine lactate reduces choroidal neovascularization in a laser-injury model in the rat [J].

Ciulla, TA ;

Criswell, MH ;

Danis, RP ;

Williams, JI ;

McLane, MP ;

Holroyd, KJ .

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2003, 23 (06) :808-814

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