Preparation of biodegradable magnetic microspheres with poly(lactic acid)-coated magnetite

被引：85

作者：

Zhao, Hong ^{[1
]}

Saatchi, Katayoun ^{[1
]}

Haefeli, Urs O. ^{[1
]}

机构：

[1] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 10期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

Magnetite; Coating; Stabilization; PLA; PLGA; Poly(lactic acid); Poly (lactide-co-glycolide); Magnetic microspheres; Biodegradability; IRON-OXIDE NANOPARTICLES; BIOMEDICAL APPLICATIONS; FE3O4; NANOPARTICLES; PARTICLES; ADSORPTION; AGENTS; ACIDS;

D O I：

10.1016/j.jmmm.2009.02.038

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Poly(lactic acid) (PLA)-coated magnetic nanoparticles were made using uncapped PLA with free carboxylate groups. The physical properties of these particles were compared to those of oleate-coated or oleate/sulphonate bilayer (W40) coated magnetic particles. Magnetic microspheres (MMS) with the matrix material poly(lactide-co-glycolide) (PLGA) or PLA were then formed by the emulsion solvent extraction method with encapsulation efficiencies of 40%, 83% and 96% for oleate, PLA and oleate/sulfonate-coated magnetic particles, respectively. MMS made from PLA-coated magnetite were hemocompatible and produced no hemolysis, whereas the other MMS were hemolytic above 0.3mg/mL of blood. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1356 / 1363

页数：8

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