Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase

被引：15

作者：

Guetsova, ML

Crother, TR

Taylor, MW

Daignan-Fornier, B

机构：

[1] CNRS, UPR 9026, IBGC, F-33077 Bordeaux, France

[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 09期

关键词：

D O I：

10.1128/JB.181.9.2984-2986.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A new Saccharomyces cerevisiae gene, XPT1, was isolated as a multicopy suppressor of a hypoxanthine phosphoribosyl transferase (HPRT) defect. Disruption of XPT1 affects xanthine utilization in vivo and results in a severe reduction of xanthine phosphoribosyl transferase (XPRT) activity while HPRT is unaffected. We conclude that XPT1 encodes XPRT in yeast.

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页码：2984 / 2986

页数：3

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