Characterization of crystalline phase-transformations in theophylline by time-domain terahertz spectroscopy

被引：44

作者：

Upadhya, P. C. ^{[1
]}

Nguyen, K. L.

Shen, Y. C.

Obradovic, J.

Fukushige, K.

Griffiths, R.

Gladden, L. F.

Davies, A. G.

Linfield, E. H.

机构：

[1] Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England

[3] Univ Cambridge, Dept Chem Engn, Cambridge CB2 3RA, England

[4] TeraView Ltd, Cambridge, England

来源：

SPECTROSCOPY LETTERS | 2006年 / 39卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

intermolecular forces; lattice phonons; pharmaceutical; terahertz spectroscopy; theophylline;

D O I：

10.1080/00387010600636916

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Time-domain terahertz (THz) spectroscopy has been used to characterize polymorphic transformations in polycrystalline theophylline, a widely used pharmaceutical compound. On transformation, different intermolecular bonding arrangements arise owing to changes in the lattice structure of the molecular crystal, leading to distinct THz spectral signatures. Temperature-dependent THz absorption measurements in anhydrous theophylline confirm that the observed vibrational modes originate from phonons within the crystal structure.

引用

页码：215 / 224

页数：10

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