Rhodium-catalyzed direct C-H addition of 4,4-dimethyl-2-oxazoline to alkenes

被引：46

作者：

Wiedemann, SH

Bergman, RG ^{[1
]}

Eman, JA

机构：

[1] Univ Calif Berkeley, Dept Chem, Ctr New Direct Organ Synth, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Chem Sci, Berkeley, CA 94720 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 10期

关键词：

D O I：

10.1021/ol049417q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the preparation of 2-substituted oxazolines by rhodium-catalyzed coupling of alkenes with 4,4-dimethyl-2-oxazoline is reported. The oxazoline products are obtained in good yield with excellent selectivity for the linear product. A variety of alkene substitution patterns and functional groups are tolerated. This procedure represents an attractive alternative to hydroesterification because it does not involve the manipulation of CO gas.

引用

页码：1685 / 1687

页数：3

共 36 条

[1]

BURK PL, 1983, Patent No. 0092350

[2]

CASTANET Y, 1993, Patent No. 449693

[3] Generation of alkyl(dicarbonyl)(chloro)-ruthenium dimers in the ruthenium-catalyzed addition of alkyl formates to ethylene [J].