Microbial reduction of ethyl 2-oxo-4-phenylbutyrate.: Searching for R-enantioselectivity.: New access to the enalapril like ACE inhibitors

被引：22

作者：

Bergo de Lacerda, Paulo S. ^{[1
]}

Ribeiro, Joyce Benzaquem

Leite, Selma G. F.

Ferrara, Maria Antonieta

Coelho, Ricardo B.

Bon, Elba P. S.

Luiz da Silva Lima, Edson

Antunes, O. A. C.

机构：

[1] FarManguinhos Fundacao Oswaldo Cruz, BR-20000 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Quim, BR-21945970 Rio de Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Escola Quim, BR-21945970 Rio de Janeiro, Brazil

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 08期

关键词：

D O I：

10.1016/j.tetasy.2006.04.008

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Herein, different microorganisms were tested in the enantio selective reduction of ethyl 2-oxo-4-phenylbutyrate in aqueous medium for the preparation of ethyl (R)-2-hydroxy-4-phenylbutyrate, a key intermediate in the production of angiotensin converting enzyme (ACE) inhibitors. The use of Pichia angusta led to the (R)-enantiomer in 81% ee. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1186 / 1188

页数：3

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