Synthesis of selenium-containing polysaccharides and evaluation of antioxidant activity in vitro

被引：180

作者：

Wang, Junlong ^{[1
]}

Zhao, Baotang ^{[1
]}

Wang, Xiaofang ^{[1
]}

Yao, Jian ^{[1
]}

Zhang, Ji ^{[1
]}

机构：

[1] NW Normal Univ, Coll Life Sci, Bioact Prod Engn Res Ctr Gansu Distinct Plants, Lanzhou 730070, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 05期

关键词：

Artemisia sphaerocephala; Polysaccharides; Selenium; Antioxidant activity; DERIVATIVES;

D O I：

10.1016/j.ijbiomac.2012.08.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Selenium (Se) is an essential trace element for human beings and many other forms of life. Organic Se from natural foods has higher bioavailability and is safer than inorganic Se species. In the present study, selenium-containing derivatives of Artemisia sphaerocephala polysaccharide with the highest Se content of 1703 mu g/g were synthesized using H2SeO3/HNO3 and BaCl2 as a catalyst. The effects of the ratio of HNO3 concentration and reaction temperature were investigated. Results of Raman and C-13 NMR spectroscopy indicated that C-6 substitution was predominant in selenized polysaccharide. A sharp decrease in M-w was observed in the selenized reaction due to the acid environment. The in vitro antioxidant results suggest that selenium-containing polysaccharide should be applied as a novel selenium source in dietary supplements, with potent antioxidant properties. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.

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页码：987 / 991

页数：5

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