Delta4, an endothelial specific Notch ligand expressed at sites of physiological and tumor angiogenesis

被引：240

作者：

Mailhos, C

Modlich, U

Lewis, J

Harris, A

Bicknell, R

Ish-Horowicz, D

机构：

[1] Imperial Canc Res Fund, Dev Genet Labs, London WC2A 3PX, England

[2] Imperial Canc Res Fund, Vertebrate Dev Labs, London WC2A 3PX, England

[3] Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Imperial Canc Res Fund,Mol Angiogenesis Grp, Oxford OX3 9DU, England

[4] Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Imperial Canc Res Fund,Mol Oncol Grp, Oxford OX3 9DU, England

来源：

DIFFERENTIATION | 2001年 / 69卷 / 2-3期

关键词：

vasculature; arterial endothelium; embryonic development; cancer;

D O I：

10.1046/j.1432-0436.2001.690207.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Delta-Notch signalling regulates cell-fate choices in a variety of tissues during development. We report the expression of Delta4 (Dl4) in arterial endothelium during mouse embryogenesis and in the endothelium of tumor blood vessels. The expression of Dl4 in the mouse begins at 8 dpc in the dorsal aortae, umbilical artery and the heart. Subsequent expression is restricted to smaller vessels and capillaries and is reduced in most adult tissues. However, it is high in the vasculature of xenograft human tumors in the mouse, in endogenous human tumors and is regulated by hypoxia. These data implicate Dl4 and the Notch signalling pathway in angiogenesis and suggest possible new targets for anti-angiogenic tumor therapy.

引用

页码：135 / 144

页数：10

共 56 条

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