Identification of the true human orthologue of the mouse Zp1 gene:: evidence for greater complexity in the mammalian zona pellucida?

被引：89

作者：

Hughes, DC ^{[1
]}

Barratt, CLR

机构：

[1] Birmingham Womens Hosp, Reprod Biol & Genet Grp, Assisted Concept Unit, Birmingham B15 2TG, W Midlands, England

[2] Univ Birmingham, Dept Med, Wolfson Labs, Birmingham, W Midlands, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1447卷 / 2-3期

关键词：

oocyte; zona pellucida; ZP1; ZP2; ZP3; ZPB;

D O I：

10.1016/S0167-4781(99)00181-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：303 / 306

页数：4

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