Progress in the dissection and manipulation of plant vitamin E biosynthesis

被引:50
作者
DellaPenna, D [1 ]
Last, RL [1 ]
机构
[1] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48823 USA
关键词
D O I
10.1111/j.1399-3054.2006.00611.x
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Plants contain many unique biosynthetic pathways producing a diverse array of natural products that are important for plant function, agriculture, and human nutrition. The tocochromanols define one such class of compounds, comprised of four tocopherols and four tocotrienols that are collectively termed vitamin E. Tocochromanols are synthesized only by plants and other oxygenic, photosynthetic organisms, and the eight individual compounds vary widely in their vitamin E activities. Vitamin E was recognized as an essential component in mammalian diets in the 1920s and the tocochromanol biosynthetic pathway elucidated from radiotracer studies in the mid 1980s. However, it is only recently that genetic and genomics-based approaches in model photosynthetic organisms have allowed the genes and proteins for tocochromanol synthesis to be isolated, setting the stage for targeted manipulation of tocochromanol levels and types in various crops. This article reviews advancements in our molecular and genetic understanding of the tocochromanol biosynthetic pathway in the model photosynthetic organisms Arabidopsis thaliana and Synechocystis sp. PCC6803 and highlights ongoing efforts to use this knowledge to manipulate the levels of this essential nutrient in food crops.
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收藏
页码:356 / 368
页数:13
相关论文
共 76 条
[61]   2-METHYL-6-PHYTYLQUINOL AND 2,3-DIMETHYL-5-PHYTYLQUINOL AS PRECURSORS OF TOCOPHEROL SYNTHESIS IN SPINACH-CHLOROPLASTS [J].
SOLL, J ;
SCHULTZ, G .
PHYTOCHEMISTRY, 1980, 19 (02) :215-218
[62]   HYDROGENATION OF GERANYLGERANIOL - 2 PATHWAYS EXIST IN SPINACH-CHLOROPLASTS [J].
SOLL, J ;
SCHULTZ, G ;
RUDIGER, W ;
BENZ, J .
PLANT PHYSIOLOGY, 1983, 71 (04) :849-854
[63]   Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductase [J].
Tanaka, R ;
Oster, U ;
Kruse, E ;
Rüdiger, W ;
Grimm, B .
PLANT PHYSIOLOGY, 1999, 120 (03) :695-704
[64]  
TAYLOR P, 1981, CHEM IND-LONDON, P722
[65]   Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E [J].
Terasawa, Y ;
Ladha, Z ;
Leonard, SW ;
Morrow, JD ;
Newland, D ;
Sanan, D ;
Packer, L ;
Traber, MG ;
Farese, RV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (25) :13830-13834
[66]   Vitamin E trafficking [J].
Traber, MG ;
Burton, GW ;
Hamilton, RL .
VITAMIN E AND HEALTH, 2004, 1031 :1-12
[67]   Vitamin E regulation [J].
Traber, MG .
CURRENT OPINION IN GASTROENTEROLOGY, 2005, 21 (02) :223-227
[68]   Vitamin E, nuclear receptors and xenobiotic metabolism [J].
Traber, MG .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2004, 423 (01) :6-11
[69]   Vitamin E in humans: Demand and delivery [J].
Traber, MG ;
Sies, H .
ANNUAL REVIEW OF NUTRITION, 1996, 16 :321-347
[70]   Molecular mechanisms of vitamin E transport [J].
Traber, MG ;
Arai, H .
ANNUAL REVIEW OF NUTRITION, 1999, 19 :343-355