Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis

被引：74

作者：

Wu, PL ^{[1
]}

Lin, FW

Wu, TS

Kuoh, CS

Lee, KH

Lee, SJ

机构：

[1] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[2] Natl Cheng Kung Univ, Dept Biol, Tainan 701, Taiwan

[3] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[4] Natl Hlth Res Inst, Div Biotechnol & Pharmaceut Res, Taipei 221, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 03期

关键词：

Begonia nantoensis; Begoniaceae; cucurbitacin; dihydrocucurbitacin; cytotoxicity;

D O I：

10.1248/cpb.52.345

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new compounds: begonanline (1), nantoamide (2) and methyl (S)-glycerate (3) as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4), dihydrocucurbitacin B (5), cucurbitacin E (6), dihydrocucurbitacin E (7), cucurbitacin 1 (8), and (-)-auranamide (9) showed cytotoxicity against four human cancer cell lines. 3beta,22alpha-Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.

引用

页码：345 / 349

页数：5

共 40 条

[1] Cucurbitacins of Cucumis prophetarum and Cucumis prophetarum [J].