Cucurbitacins of Cucumis prophetarum and Cucumis prophetarum

被引：42

作者：

Afifi, MS

Ross, SA

elSohly, MA

Naeem, ZE

Halaweish, FT

机构：

[1] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura, Egypt

[2] Univ Mississippi, Pharmaceut Sci Res Inst, Natl Ctr Dev Nat Prod, University, MS 38677 USA

[3] Univ Mississippi, Dept Pharmacognosy, University, MS 38677 USA

[4] Univ Mississippi, Sch Pharm, Dept Pharmaceut, University, MS 38677 USA

来源：

JOURNAL OF CHEMICAL ECOLOGY | 1999年 / 25卷 / 04期

关键词：

cucurbitacins; isocucurbitacin; dihydrocucurbitacin; Cucumis prophetarum;

D O I：

10.1023/A:1020801002471

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cucurbitacin B, isocucurbitacin B, dihydrocucurbitacin B, cucurbitacin E, dihydrocucurbitacin E, isocucurbitacin D, dihydroisocucurbitacin D, cucurbitacin I, dihydrocucurbitacin I, cucurbitacin Q1, and dihydrocucurbitacin Q1 were identified for the first time as constituents of Cucumis prophetarum L. Cucurbitacin B, cucurbitacin O, cucurbitacin P, cucurbitacin Q1, dihydrocucurbitacin Q1, isocucurbitacin E, and dihydroisocucurbitacin E also were identified as constituents of C. prophetarum Jusl. ssp. Dissectus. Isocucurbitacin E and dihydroisocucurbitacin E were isolated for the first time in nature. The chemical structures were determined with extensive spectroscopic analysis including 2D NMR, H-1 NMR, C-13 NMR, correlated spectroscopy (COSY), heteronuclear chemical shift correlation (HETCOR), attached proton test (APT), and distortionless enhancement by polarization transfer (DEPT).

引用

页码：847 / 859

页数：13

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