A citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice

被引：83

作者：

Kawaguchi, K

Kikuchi, S

Hasunuma, R

Maruyama, H

Yoshikawa, T

Kumazawa, Y

机构：

[1] Kitasato Univ, Sch Sci, Dept Biosci, Sagamihara, Kanagawa 2288555, Japan

[2] Kitasato Univ, Sch Pharmaceut Sci, Med Plant Garden, Sagamihara, Kanagawa 2288555, Japan

[3] Kitasato Univ, Sch Allied Hlth Sci, Dept Pathol, Sagamihara, Kanagawa 2288555, Japan

[4] Kitasato Univ, Sch Pharmaceut Sci, Dept Phytochem & Pharmacognosy, Tokyo 1088641, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2004年 / 27卷 / 05期

关键词：

Salmonella-infection; endotoxin shock; flavonoid; hesperidin; blood coagulation factor; Limulus reaction;

D O I：

10.1248/bpb.27.679

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Administration of a citrus flavonoid hesperidin (HES) to mice before LPS challenge significantly reduced tumor necrosis factor (TNF)-alpha production in a dose-dependent manner. Treatment of HES 3 h before intraperitoneal (i.p.) infection with 10(8) CFU Salmonella typhimurium aroA resulted in rescue from lethal shock as similar to LPS-nonresponder mice. Not only bacterial numbers in livers and spleens but also plasma LPS levels significantly decreased by pretreatment with HES. In addition, HES markedly suppressed plasma levels of TNF-alpha and high mobility group box chromosomal protein 1 (HMGB-1), decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection. Pretreatment of LPS with HES suppressed the chromogenic Limulus reaction.

引用

页码：679 / 683

页数：5

共 19 条

[1]

A novel inhibitor of bacterial endotoxin derived from cinnamon bark [J].