Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment

被引:97
作者
Blais, Mathieu
Parenteau-Bareil, Remi
Cadau, Sebastien
Berthod, Francois [1 ]
机构
[1] Univ Laval, Ctr Rech, CHU Quebec, Ctr LOEX, Quebec City, PQ G1J 1Z4, Canada
基金
加拿大健康研究院;
关键词
Skin grafts; Tissue regeneration; Transplantation; Neuron; Epidermis; Cell biology; FOLLICULAR UNIT TRANSPLANTATION; DERMAL STEM-CELLS; HAIR FOLLICLE; IN-VITRO; ADULT SKIN; CULTURED EPITHELIUM; SENSORY PERCEPTION; RECONSTRUCTED SKIN; CENTRAL MECHANISM; PAIN SENSITIVITY;
D O I
10.5966/sctm.2012-0181
中图分类号
Q813 [细胞工程];
学科分类号
100113 [医学细胞生物学];
摘要
Burns not only destroy the barrier function of the skin but also alter the perceptions of pain, temperature, and touch. Different strategies have been developed over the years to cover deep and extensive burns with the ultimate goal of regenerating the barrier function of the epidermis while recovering an acceptable aesthetic aspect. However, patients often complain about a loss of skin sensation and even cutaneous chronic pain. Cutaneous nerve regeneration can occur from the nerve endings of the wound bed, but it is often compromised by scar formation or anarchic wound healing. Restoration of pain, temperature, and touch perceptions should now be a major challenge to solve in order to improve patients' quality of life. In addition, the cutaneous nerve network has been recently highlighted to play an important role in epidermal homeostasis and may be essential at least in the early phase of wound healing through the induction of neurogenic inflammation. Although the nerve regeneration process was studied largely in the context of nerve transections, very few studies have been aimed at developing strategies to improve it in the context of cutaneous wound healing. In this concise review, we provide a description of the characteristics of and current treatments for extensive burns, including tissue-engineered skin approaches to improve cutaneous nerve regeneration, and describe prospective uses for autologous skin-derived adult stem cells to enhance recovery of the skin's sense of touch.
引用
收藏
页码:545 / 551
页数:7
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