Disturbed visual processing contributes to impaired reading in Alzheimer's disease

被引:13
作者
Glosser, G
Baker, KM
de Vries, JJ
Alavi, A
Grossman, M
Clark, CM
机构
[1] Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
alexia; agnosia; dementia;
D O I
10.1016/S0028-3932(01)00165-8
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The relationship between visual processing dysfunction and oral reading impairment was investigated in 17 patients with probable or possible Alzheimer's disease (AD). When dementia severity was controlled, a significant relationship was found between single word oral reading impairments and difficulties discriminating words written in different fonts and photographs of objects in different orientations, which are all functions believed to be dependent on the integrity of loft ventral temporal-occipital visual association regions. By contrast. there was no significant relationship between reading performance and the score on a test of spatial localization, believed to be more dependent on parietal lobe function. There was also no relationship between reading ability and discrimination of unfamiliar faces, a function thought to engage right inferotemporal lobe structures. In contrast to the significant association between impaired reading and certain visual processes, when dementia severity was controlled, there was no relationship between reading and lexical semantic impairment. These results highlight the contribution of visual processing deficits to impaired oral reading in AD and further suggest that this association may derive from neuropathological changes in areas of the left temporal occipital lobes specialized far high-level visual processing. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:902 / 909
页数:8
相关论文
共 94 条
[51]   Object recognition difficulty in visual apperceptive agnosia [J].
Grossman, M ;
Galetta, S ;
DEsposito, M .
BRAIN AND COGNITION, 1997, 33 (03) :306-342
[52]  
Grossman M, 1996, NEUROPSY NEUROPSY BE, V9, P70
[53]   SEMANTIC MEMORY IMPAIRMENT IN ALZHEIMERS-DISEASE - FAILURE OF ACCESS OR DEGRADED KNOWLEDGE [J].
HODGES, JR ;
SALMON, DP ;
BUTTERS, N .
NEUROPSYCHOLOGIA, 1992, 30 (04) :301-314
[54]   THE NATURE OF THE NAMING DEFICIT IN ALZHEIMERS AND HUNTINGTONS-DISEASE [J].
HODGES, JR ;
SALMON, DP ;
BUTTERS, N .
BRAIN, 1991, 114 :1547-1558
[55]   LOSS OF SEMANTIC MEMORY - IMPLICATIONS FOR THE MODULARITY OF MIND [J].
HODGES, JR ;
PATTERSON, K ;
TYLER, LK .
COGNITIVE NEUROPSYCHOLOGY, 1994, 11 (05) :505-542
[56]   Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways [J].
Hof, PR ;
Vogt, BA ;
Bouras, C ;
Morrison, JH .
VISION RESEARCH, 1997, 37 (24) :3609-3625
[57]   OBJECT RECOGNITION DEFICIT IN ALZHEIMERS-DISEASE - POSSIBLE DISCONNECTION OF THE OCCIPITO-TEMPORAL COMPONENT OF THE VISUAL-SYSTEM [J].
HOF, PR ;
BOURAS, C .
NEUROSCIENCE LETTERS, 1991, 122 (01) :53-56
[58]   SEMANTIC IMPAIRMENT AND ANOMIA IN ALZHEIMERS-DISEASE [J].
HUFF, FJ ;
CORKIN, S ;
GROWDON, JH .
BRAIN AND LANGUAGE, 1986, 28 (02) :235-249
[59]   CONTRAST SENSITIVITY DYSFUNCTION IN ALZHEIMERS-DISEASE [J].
HUTTON, JT ;
MORRIS, JL ;
ELIAS, JW ;
POSTON, JN .
NEUROLOGY, 1993, 43 (11) :2328-2330
[60]   EYE TRACKING DYSFUNCTION IN ALZHEIMER-TYPE DEMENTIA [J].
HUTTON, JT ;
NAGEL, JA ;
LOEWENSON, RB .
NEUROLOGY, 1984, 34 (01) :99-102