Cryptococcus gattii: a resurgent fungal pathogen

被引：79

作者：

Chaturvedi, Vishnu ^{[1
,2
]}

Chaturvedi, Sudha ^{[1
,2
]}

机构：

[1] New York State Dept Hlth, Mycol Lab, Wadsworth Ctr, Albany, NY 12208 USA

[2] SUNY Albany, Dept Biomed Sci, Sch Publ Hlth, Albany, NY 12208 USA

来源：

TRENDS IN MICROBIOLOGY | 2011年 / 19卷 / 11期

基金：

美国国家卫生研究院;

关键词：

NEOFORMANS VAR.-GATTII; VANCOUVER-ISLAND; BRITISH-COLUMBIA; SUPEROXIDE-DISMUTASE; VARIETIES; EPIDEMIOLOGIC DIFFERENCES; IMMUNOCOMPETENT HOSTS; ENVIRONMENTAL SOURCES; PACIFIC-NORTHWEST; NATURAL HABITAT;

D O I：

10.1016/j.tim.2011.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cryptococcus gattii and Cryptococcus neoformans are causal agents of cryptococcosis, which manifests as pneumonia and meningitis. C. gattii has recently received widespread attention owing to outbreaks in British Columbia, Canada and the US Pacific Northwest. The biology of this tree-dwelling yeast is relatively unexplored, and there are few clues about how it causes infections in humans and animals. In this review, we summarize recent discoveries about C. gattii genetics and its ecological niche and highlight areas ripe for future exploration. Increased focus on epidemiology, ecological modeling and host-pathogen interactions is expected to yield a better understanding of this enigmatic yeast, and ultimately lead to better measures for its control.

引用

页码：564 / 571

页数：8

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