How nascent phagosomes mature to become phagolysosomes

被引：204

作者：

Fairn, Gregory D. ^{[2
]}

Grinstein, Sergio ^{[1
]}

机构：

[1] Hosp Sick Children, Cell Biol Program, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

[2] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada

来源：

TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 08期

基金：

加拿大健康研究院;

关键词：

phagocytosis; phagosome maturation; phosphoinositide; GTPase; calcium; autophagy; membrane fusion; membrane fission; APOPTOTIC CELLS; ACID SPHINGOMYELINASE; NUCLEOTIDE EXCHANGE; TETHERING COMPLEX; AUTOPHAGY PATHWAY; MEMBRANE-FUSION; VACUOLE FUSION; MATURATION; SALMONELLA; RAB5;

D O I：

10.1016/j.it.2012.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Phagocytosis mediates the clearance of apoptotic bodies and also the elimination of microbial pathogens. The nascent phagocytic vacuole formed upon particle engulfment lacks microbicidal and degradative activity. These capabilities are acquired as the phagosome undergoes maturation; a progressive remodeling of its membrane and contents that culminates in the formation of phagolysosomes. Maturation entails orderly sequential fusion of the phagosomal vacuole with specialized endocytic and secretory compartments. Concomitantly, the phagosomal membrane undergoes both inward and outward vesiculation and tubulation followed by fission, thereby recycling components and maintaining its overall size. Here, we summarize what is known about the molecular machinery that governs this complex metamorphosis of phagosome maturation.

引用

页码：397 / 405

页数：9

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