Sorting nexins - Unifying trends and new perspectives

被引：161

作者：

Carlton, J ^{[1
]}

Bujny, M ^{[1
]}

Rutherford, A ^{[1
]}

Cullen, P ^{[1
]}

机构：

[1] Sch Med Sci Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

TRAFFIC | 2005年 / 6卷 / 02期

关键词：

BAR domain; endosomal sorting; PX domain; SNX/retromer; sorting nexin;

D O I：

10.1111/j.1600-0854.2005.00260.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The sorting nexins (SNXs) are a family of PX domain-containing proteins found in yeast and mammalian cells that have been proposed to regulate intracellular trafficking. Mammalian SNXs have been suggested to function variously in pro-degradative sorting, internalization, endosomal recycling, or simply in endosomal sorting. In yeast, the defining function for these proteins is a regulation of cargo retrieval. Here we examine recent data on the SNX family of proteins and attempt to draw out unifying themes between the work performed in yeast and mammalian systems.

引用

页码：75 / 82

页数：8

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