Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key

被引：58

作者：

Vavouri, T

McEwen, GK

Woolfe, A

Gilks, WR

Elgar, G

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[2] Inst Publ Hlth, MRC Biostat Unit, Cambridge CB2 2SR, England

[3] Queen Mary Univ London, Sch Biol Sci, London E1 4NS, England

来源：

TRENDS IN GENETICS | 2006年 / 22卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tig.2005.10.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Many conserved non-coding elements (CNEs) in vertebrate genomes have been shown to function as tissue-specific enhancers. However, the target genes of most CNEs are unknown. Here we show that the target genes of duplicated CNEs can be predicted by considering their neighbouring paralogous genes. This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene.

引用

页码：5 / 10

页数：6

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