Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion

被引：19

作者：

Yang, J. ^{[1
]}

Klaidman, L. K. ^{[1
]}

Adams, J. D. ^{[1
]}

机构：

[1] Univ So Calif, Sch Pharm, Los Angeles, CA 90089 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 02期

关键词：

D O I：

10.2174/1389557024605483

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.

引用

页码：125 / 134

页数：10

共 126 条

[1]

Adams J, 2000, OXIDAT STRESS DIS, P55

[2]

Adams J.D., 1996, BURGERS MED CHEM DRU, V3, P261

[3]

Adams James D., 1999, Society for Neuroscience Abstracts, V25, P1846

[4] Apoptosis and oxidative stress in the aging brain [J].

Adams, JD ;

Mukherjee, SK ;

Klaidman, LK ;

Chang, ML ;

Yasharel, R .

PHARMACOLOGICAL INTERVENTION IN AGING AND AGE-ASSOCIATED DISORDERS: PROCEEDINGS OF THE SIXTH CONGRESS OF THE INTERNATIONAL ASSOCIATION OF BIOMEDICAL GERONTOLOGY, 1996, 786 :135-151

[5]

ADAMS JD, 1999, CHEM NEURODEGENERATI, P231

[6]

Akimoto T, 2000, CHEM PHARM BULL, V48, P467

[7]

Althaus F., 1987, ADP RIBOSYLATION PRO, P45

[8] Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats [J].