Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion

被引：19

作者：

Yang, J. ^{[1
]}

Klaidman, L. K. ^{[1
]}

Adams, J. D. ^{[1
]}

机构：

[1] Univ So Calif, Sch Pharm, Los Angeles, CA 90089 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 02期

关键词：

D O I：

10.2174/1389557024605483

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.

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页码：125 / 134

页数：10

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