Baicalin plays an anti-inflammatory role through reducing nuclear factor-κB and p38 phosphorylation in S. aureus-induced mastitis

被引：133

作者：

Guo Mengyao ^{[1
]}

Zhang Naisheng ^{[1
]}

Li Depeng ^{[1
]}

Liang Dejie ^{[1
]}

Liu Zhicheng ^{[1
]}

Li Fenyang ^{[1
]}

Fu Yunhe ^{[1
]}

Cao Yongguo ^{[1
]}

Deng Xuming ^{[1
]}

Yang Zhengtao ^{[1
]}

机构：

[1] Jilin Univ, Dept Clin Vet Med, Coll Anim Sci & Vet Med, Changchun 130062, Jilin Province, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2013年 / 16卷 / 02期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

Baicalin; S. aureus mastitis; Anti-inflammation; Nuclear factor-kappaB (NF-kappa B); p38; STAPHYLOCOCCUS-AUREUS; EPITHELIAL-CELLS; BOVINE MASTITIS; EXPRESSION; PATHOGENESIS; INFECTIONS; INHIBITION; IL-1-BETA; APOPTOSIS; RELEASE;

D O I：

10.1016/j.intimp.2013.03.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Mastitis is an inflammatory disease caused by microbial infection. Staphylococcus aureus is the major etiological microorganism responsible for both clinical and subclinical mastitis in dairy cows. A mouse model of S. aureus mastitis is available. Baicalin is isolated from Scutellaria and is known to have anti-inflammatory properties. This study was designed to evaluate the effects of baicalin in S. aureus mastitis. In the present study, the mouse model was infected with S. aureus to cause mammary gland inflammation. Baicalin treatment was administered from 6 h until 24 h after infection. Baicalin significantly attenuated inflammatory cell infiltration and decreased levels of TNF-alpha, IL-beta, and IL-6. Further studies revealed that baicalin downregulated phosphorylation of NF-kappa B and p38 in the mammary gland with S. aureus mastitis. Our results demonstrated that baicalin reduced the expression of the proinflammatory cytokines TNF-alpha, IL-beta, and IL-6 by inhibiting NF-kappa B and p38 phosphorylation and mRNA expression. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：125 / 130

页数：6

共 36 条

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