In-target produced [11C]methane: Increased specific radioactivity

被引：63

作者：

Andersson, Jan ^{[1
]}

Truong, Phong ^{[1
]}

Halldin, Christer ^{[1
]}

机构：

[1] Karolinska Univ Hosp, Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, S-17176 Stockholm, Sweden

来源：

APPLIED RADIATION AND ISOTOPES | 2009年 / 67卷 / 01期

关键词：

Specific radioactivity; PET; Carbon-11; Methyl triflate; Methyl iodide; HUMAN BRAIN; PET; RADIOLIGAND; TRIFLATE; DERIVATIVES; TRANSPORTER; IODINATION; MONKEY; AGENTS;

D O I：

10.1016/j.apradiso.2008.09.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The N-14(rho, alpha)C-11 reaction on N-2-O-2 or N-2-H-2 gaseous systems as targets in proton bombardment allows for the production of [C-11]CO2 and [C-11]CH4. We report the target production of [C-11]CH4 and the gas phase iodination to produce [C-11]CH3I with high specific radioactivity (SA). SA was calculated for four different radiopharmaceuticals produced in-house from both target produced [C-11]CO2 and [C-11]CH4. For [C-11]raclopride we obtained an average SA of 3908 GBq/mu mol (106000 Ci/mmol) at the end of bombardment for the last 52 productions, which is a 32-fold increase compared to when using the in-house [C-11]CO2 target. (C) 2008 Elsevier Ltd. All rights reserved.

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页码：106 / 110

页数：5

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