[11C]-dimethylamine as a labeling agent for PET biomarkers

被引：5

作者：

Jacobson, Orit ^{[1
]}

Mishani, Eyal ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Med Biophys & Nucl Med, IL-91120 Jerusalem, Israel

来源：

APPLIED RADIATION AND ISOTOPES | 2008年 / 66卷 / 02期

关键词：

C-11]-dimethylamine; PET;

D O I：

10.1016/j.apradiso.2007.08.012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The dimethylamine functional group is a common component of the chemical structure of numerous drugs. The most commonly used synthetic route for carbon-11 labeled radiopharmaceuticals which contain the diniethylamine group is via C-11 methylation of the monomethyl amine precursors. Here we describe the radiosynthesis of [C-11]dimethylamine (1) and its application in the direct labeling of several positron emission tomography (PET) imaging agents by-passing the preparation of the monomethyl amine precursors. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：188 / 193

页数：6

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