Radiopharmaceutical chemistry for positron emission tomography

被引：57

作者：

Elsinga, PH ^{[1
]}

机构：

[1] Univ Groningen Hosp, PET Ctr, NL-9700 RB Groningen, Netherlands

来源：

METHODS | 2002年 / 27卷 / 03期

关键词：

radiopharmaceuticals; positron emission tomography; fluorine-18; carbon-11;

D O I：

10.1016/S1046-2023(02)00076-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Radiopharmaceutical chemistry includes the selection, preparation, and preclinical evaluation of radiolabeled compounds. This paper describes selection criteria for candidates for positron emission tomography (PET) investigations. Practical aspects of nucleophilic and electrophilic F-18-fluorinations and C-11-methylations are described. These aspects include production of fluorine-18 and carbon-11, workup of fluorine-18, F-18 radiochemistry, production of [C-11]methyl iodide and triflate, and C-11-methylation radiochemistry. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：208 / 217

页数：10

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