Catalytic hydroxyl/amine dyads within serine proteases

被引：128

作者：

Paetzel, M

Dalbey, RE

机构：

[1] Department of Chemistry, Ohio State University, Columbus

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(96)10065-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 'catalytic triad' mechanism, which involves a serine, histidine and aspartic acid, has become synonymous with serine proteases. However, recently, mechanistically novel serine proteases have been discovered. These proteases use hydroxyl/epsilon-amine or hydroxyl/alpha-amine 'catalytic dyads' as their reactive centers.

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页码：28 / 31

页数：4

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