The price of immunity

被引：159

作者：

Goldszmid, Romina S. ^{[1
]}

Trinchieri, Giorgio ^{[1
]}

机构：

[1] NCI, Expt Immunol Lab, Canc & Inflammat Program, Ctr Canc Res,US Natl Inst Hlth, Frederick, MD 21701 USA

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 10期

关键词：

RECONSTITUTION INFLAMMATORY SYNDROME; GENOME-WIDE ASSOCIATION; CD4(+) T-CELLS; MICROBIAL TRANSLOCATION; INTESTINAL MICROBIOTA; PREVENTS DEVELOPMENT; DENDRITIC CELLS; GUT MICROBIOTA; HIV-INFECTION; HEPATITIS-B;

D O I：

10.1038/ni.2422

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Resistance mechanisms of the innate and adaptive immune responses prevent the colonization of foreign organisms in unwanted anatomical sites and participate in tissue repair and restoration of homeostasis after damage induced either by the invasion of pathogenic microbes or by the organism's response to them. The intensity of the response is controlled and limited by positive and negative feedback circuits that aim at preventing collateral tissue damage. In this Review we will discuss the protective and pathogenic effects of host-commensal microbiota mutualism on the immune response and illustrate some examples of collateral tissue and systemic damage caused by immunity to pathogens.

引用

页码：932 / 938

页数：7

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