FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx

被引：27

作者：

Dutra, Roberta Lelis ^{[2
]}

de Carvalho, Marcos Brasilino ^{[3
,4
]}

dos Santos, Marcelo ^{[5
]}

da Cunha Mercante, Ana Maria ^{[6
]}

Gazito, Diana ^{[7
]}

de Cicco, Rafael ^{[8
]}

Tajara, Eloiza Helena ^{[10
]}

Louro, Iuri Drumond ^{[11
]}

Alvares da Silva, Adriana Madeira ^{[1
]}

机构：

[1] Univ Fed Espirito Santo, Dept Biol, Alegre, ES, Brazil

[2] Univ Sao Paulo, Fac Med, Sao Paulo, Brazil

[3] Hosp Heliopolis, Mol Biol Lab, Sao Paulo, Brazil

[4] Hosp Heliopolis, Serv Cirurgia Cabeca & Pescoco, Sao Paulo, Brazil

[5] Univ Fed Espirito Santo, Programa Pos Grad Biotecnol, Vitoria, ES, Brazil

[6] Hosp Heliopolis, Dept Anat Patol, Sao Paulo, Brazil

[7] Assoc Beneficente Coleta Sangue, Lab Sequenciamento, Sao Paulo, Brazil

[8] Inst Canc Res, Sao Paulo, Brazil

[9] GENCAPO, Head & Neck Genome Project, Sao Paulo, Brazil

[10] Fac Med Sao Jose Rio Preto, Dept Biol Mol, Sao Paulo, Brazil

[11] Univ Fed Espirito Santo, Dept Ciencias Biol, Vitoria, ES, Brazil

来源：

PLOS ONE | 2012年 / 7卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

FACTOR RECEPTOR 4; BREAST-CANCER; GLY388ARG POLYMORPHISM; ARG(388) ALLELE; ARG388; ALLELE; TISSUE MICROARRAYS; UBIQUITIN-BINDING; NECK-CANCER; GENE; HEAD;

D O I：

10.1371/journal.pone.0050747

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Background: Fibroblast growth factor receptor 4 (FGFR4) is a member of a receptor tyrosine kinase family of enzymes involved in cell cycle control and proliferation. A common single nucleotide polymorphism (SNP) Gly388Arg variant has been associated with increased tumor cell motility and progression of breast cancer, head and neck cancer and soft tissue sarcomas. The present study evaluated the prognostic significance of FGFR4 in oral and oropharynx carcinomas, finding an association of FGFR4 expression and Gly388Arg genotype with tumor onset and prognosis. Patients and Methods: DNA from peripheral blood of 122 patients with oral and oropharyngeal squamous cell carcinomas was used to determine FGFR4 genotype by PCR-RFLP. Protein expression was assessed by immunohistochemistry (IHC) on paraffin-embedded tissue microarrays. Results: Presence of allele Arg388 was associated with lymphatic embolization and with disease related premature death. In addition, FGFR4 low expression was related with lymph node positivity and premature relapse of disease, as well as disease related death. Conclusion: Our results propose FGFR4 profile, measured by the Gly388Arg genotype and expression, as a novel marker of prognosis in squamous cell carcinoma of the mouth and oropharynx.

引用

页数：9

共 44 条

[1]

The fibroblast growth factor receptor 4 (FGFR4) Arg388 allele correlates with survival in head and neck squamous cell carcinoma [J].