Next-generation peptide vaccines for advanced cancer

被引：105

作者：

Yamada, Akira ^{[1
]}

Sasada, Tetsuro ^{[2
]}

Noguchi, Masanori ^{[3
]}

Itoh, Kyogo ^{[2
]}

机构：

[1] Kurume Univ, Res Ctr Innovat Canc Therapy, Canc Vaccine Dev Div, Kurume, Fukuoka 830, Japan

[2] Kurume Univ, Sch Med, Dept Immunol & Immunotherapy, Kurume, Fukuoka 830, Japan

[3] Kurume Univ, Res Ctr Innovat Canc Therapy, Div Clin Res, Kurume, Fukuoka 830, Japan

来源：

CANCER SCIENCE | 2013年 / 104卷 / 01期

关键词：

CELL LUNG-CANCER; REFRACTORY PROSTATE-CANCER; PHASE-II TRIAL; MULTIPEPTIDE MELANOMA VACCINE; METASTATIC COLORECTAL-CANCER; PULSED DENDRITIC CELLS; IMMUNOLOGICAL EVALUATION; CARCINOMA PATIENTS; IMMUNE-RESPONSES; ESTRAMUSTINE PHOSPHATE;

D O I：

10.1111/cas.12050

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many clinical trials of peptide vaccines have been carried out since the first clinical trial of a melanoma antigen gene-1-derived peptide-based vaccine was reported in 1995. The earlier generations of peptide vaccines were composed of one to several human leukocyte antigen class I-restricted CTL-epitope peptides of a single human leukocyte antigen type. Currently, various types of next-generation peptide vaccines are under development. In this review, we focus on the clinical trials of the following categories of peptide vaccines mainly published from 2008 to 2012: (i) multivalent long peptide vaccines; (ii) multi-peptide vaccines consisting of CTL- and helper-epitopes; (iii) peptide cocktail vaccines; (iv) hybrid peptide vaccines; (v) personalized peptide vaccines; and (vi) peptide-pulsed dendritic cell vaccines. (Cancer Sci 2013; 104: 1521)

引用

页码：15 / 21

页数：7

共 57 条

[1] DEVELOPMENT OF HIGH POTENCY UNIVERSAL DR-RESTRICTED HELPER EPITOPES BY MODIFICATION OF HIGH-AFFINITY DR-BLOCKING PEPTIDES [J].

ALEXANDER, J ;

SIDNEY, J ;

SOUTHWOOD, S ;

RUPPERT, J ;

OSEROFF, C ;

MAEWAL, A ;

SNOKE, K ;

SERRA, HM ;

KUBO, RT ;

SETTE, A ;

GREY, HM .

IMMUNITY, 1994, 1 (09) :751-761

[2] Induction of immune responses and clinical efficacy in a phase II trial of IDM-2101, a 10-epitope cytotoxic T-lymphocyte vaccine, in metastatic non-small-cell lung cancer [J].

Barve, Minal ;

Bender, James ;

Senzer, Neil ;

Cunningham, Casey ;

Greco, F. Anthony ;

McCune, David ;

Steis, Ronald ;

Khong, Hung ;

Richards, Donald ;

Stephenson, Joe ;

Ganesa, Prasanthi ;

Nemunaitis, Jackie ;

Ishioka, Glenn ;

Pappen, Beena ;

Nemunaitis, Michael ;

Morse, Michael ;

Mills, Bonnie ;

Maples, Phillip B. ;

Sherman, Jeffrey ;

Nemunaitis, John J. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (27) :4418-4425

[3] A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening [J].

Chen, YT ;

Scanlan, MJ ;

Sahin, U ;

Tureci, O ;

Gure, AO ;

Tsang, SL ;

Williamson, B ;

Stockert, E ;

Pfreundschuh, M ;

Old, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1914-1918

[4] A multipeptide vaccine is safe and elicits T-cell responses in participants with advanced stage ovarian cancer [J].

Chianese-Bullock, Kimberly A. ;

Irvin, William P., Jr. ;

Petroni, Gina R. ;

Murphy, Cheryl ;

Smolkin, Mark ;

Olson, Walter C. ;

Coleman, E'lizabeth ;

Boerner, Scott A. ;

Nail, Carmel J. ;

Neese, Patrice Y. ;

Yuan, Arlene ;

Hogan, Kevin T. ;

Slingluff, Craig L., Jr. .

JOURNAL OF IMMUNOTHERAPY, 2008, 31 (04) :420-430

[5] Novel Multi-Peptide Vaccination In Hla-A2+Hormone Sensitive Patients With Biochemical Relapse of Prostate Cancer [J].

Feyerabend, Susan ;

Stevanovic, Stefan ;

Gouttefangeas, Cecile ;

Wernet, Dorothee ;

Hennenlotter, Joerg ;

Bedke, Jens ;

Dietz, Klaus ;

Pascolo, Steve ;

Kuczyk, Markus ;

Rammensee, Hans-Georg ;

Stenzl, Arnulf .

PROSTATE, 2009, 69 (09) :917-927

[6]

Hodi FS, 2010, NEW ENGL J MED, V363, P1290

[7] Results of the first phase I clinical trial of the novel Ii-key hybrid preventive HER-2/neu peptide (AE37) vaccine [J].

Holmes, Jarrod P. ;

Benavides, Linda C. ;

Gates, Jeremy D. ;

Carmichael, Mark G. ;

Hueman, Matthew T. ;

Mittendorf, Elizabeth A. ;

Murray, James L. ;

Amin, Asna ;

Craig, Dianna ;

von Hofe, Eric ;

Ponniah, Sathibalan ;

Peoples, George E. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (20) :3426-3433

[8]

Hu XY, 1996, CANCER RES, V56, P2479

[9] Personalized peptide vaccines: A new therapeutic modality for cancer [J].

Itoh, Kyogo ;

Yamada, Akira .

CANCER SCIENCE, 2006, 97 (10) :970-976

[10] Recent Advances in Cancer Vaccines: An Overview [J].

Itoh, Kyogo ;

Yamada, Akira ;

Mine, Takashi ;

Noguchi, Masanori .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2009, 39 (02) :73-80

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