Next-generation peptide vaccines for advanced cancer

被引：105

作者：

Yamada, Akira ^{[1
]}

Sasada, Tetsuro ^{[2
]}

Noguchi, Masanori ^{[3
]}

Itoh, Kyogo ^{[2
]}

机构：

[1] Kurume Univ, Res Ctr Innovat Canc Therapy, Canc Vaccine Dev Div, Kurume, Fukuoka 830, Japan

[2] Kurume Univ, Sch Med, Dept Immunol & Immunotherapy, Kurume, Fukuoka 830, Japan

[3] Kurume Univ, Res Ctr Innovat Canc Therapy, Div Clin Res, Kurume, Fukuoka 830, Japan

来源：

CANCER SCIENCE | 2013年 / 104卷 / 01期

关键词：

CELL LUNG-CANCER; REFRACTORY PROSTATE-CANCER; PHASE-II TRIAL; MULTIPEPTIDE MELANOMA VACCINE; METASTATIC COLORECTAL-CANCER; PULSED DENDRITIC CELLS; IMMUNOLOGICAL EVALUATION; CARCINOMA PATIENTS; IMMUNE-RESPONSES; ESTRAMUSTINE PHOSPHATE;

D O I：

10.1111/cas.12050

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many clinical trials of peptide vaccines have been carried out since the first clinical trial of a melanoma antigen gene-1-derived peptide-based vaccine was reported in 1995. The earlier generations of peptide vaccines were composed of one to several human leukocyte antigen class I-restricted CTL-epitope peptides of a single human leukocyte antigen type. Currently, various types of next-generation peptide vaccines are under development. In this review, we focus on the clinical trials of the following categories of peptide vaccines mainly published from 2008 to 2012: (i) multivalent long peptide vaccines; (ii) multi-peptide vaccines consisting of CTL- and helper-epitopes; (iii) peptide cocktail vaccines; (iv) hybrid peptide vaccines; (v) personalized peptide vaccines; and (vi) peptide-pulsed dendritic cell vaccines. (Cancer Sci 2013; 104: 1521)

引用

页码：15 / 21

页数：7

共 57 条

[31] A Phase I Study of Personalized Peptide Vaccination Using 14 Kinds of Vaccine in Combination With Low-Dose Estramustine in HLA-A24-Positive Patients With Castration-Resistant Prostate Cancer [J].

Noguchi, Masanori ;

Uemura, Hirotsugu ;

Naito, Seiji ;

Akaza, Hideyuki ;

Yamada, Akira ;

Itoh, Kyogo .

PROSTATE, 2011, 71 (05) :470-479

[32] A randomized phase II trial of personalized peptide vaccine plus low dose estramustine phosphate (EMP) versus standard dose EMP in patients with castration resistant prostate cancer [J].

Noguchi, Masanori ;

Kakuma, Tatsuyuki ;

Uemura, Hirotsugu ;

Nasu, Yasutomo ;

Kumon, Hiromi ;

Hirao, Yasuhiko ;

Moriya, Fukuko ;

Suekane, Shigetaka ;

Matsuoka, Kei ;

Komatsu, Nobukazu ;

Shichijo, Shigeki ;

Yamada, Akira ;

Itoh, Kyogo .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2010, 59 (07) :1001-1009

[33] Induction of CD8+ T-Cell Responses Against Novel Glioma-Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma [J].

Okada, Hideho ;

Kalinski, Pawel ;

Ueda, Ryo ;

Hoji, Aki ;

Kohanbash, Gary ;

Donegan, Teresa E. ;

Mintz, Arlan H. ;

Engh, Johnathan A. ;

Bartlett, David L. ;

Brown, Charles K. ;

Zeh, Herbert ;

Holtzman, Matthew P. ;

Reinhart, Todd A. ;

Whiteside, Theresa L. ;

Butterfield, Lisa H. ;

Hamilton, Ronald L. ;

Potter, Douglas M. ;

Pollack, Ian F. ;

Salazar, Andres M. ;

Lieberman, Frank S. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (03) :330-336

[34] Results from a Phase I Clinical Study of the Novel Ii-Key/HER-2/neu(776-790) Hybrid Peptide Vaccine in Patients with Prostate Cancer [J].

Perez, Sonia A. ;

Kallinteris, Nikoletta L. ;

Bisias, Stratos ;

Tzonis, Panagiotis K. ;

Georgakopoulou, Katerina ;

Varla-Leftherioti, Marighoula ;

Papamichail, Michael ;

Thanos, Anastasios ;

von Hofe, Eric ;

Baxevanis, Constantin N. .

CLINICAL CANCER RESEARCH, 2010, 16 (13) :3495-3506

[35] A gynecologic oncology group phase II trial of two p53 peptide vaccine approaches: subcutaneous injection and intravenous pulsed dendritic cells in high recurrence risk ovarian cancer patients [J].

Rahma, Osama E. ;

Ashtar, Ed ;

Czystowska, Malgorzata ;

Szajnik, Marta E. ;

Wieckowski, Eva ;

Bernstein, Sarah ;

Herrin, Vincent E. ;

Shams, Mortada A. ;

Steinberg, Seth M. ;

Merino, Maria ;

Gooding, William ;

Visus, Carmen ;

DeLeo, Albert B. ;

Wolf, Judith K. ;

Bell, Jeffrey G. ;

Berzofsky, Jay A. ;

Whiteside, Theresa L. ;

Khleif, Samir N. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2012, 61 (03) :373-384

[36] Extended Dose Ipilimumab with a Peptide Vaccine: Immune Correlates Associated with Clinical Benefit in Patients with Resected High-Risk Stage IIIc/IV Melanoma [J].

Samaik, Amod A. ;

Yu, Bin ;

Yu, Daohai ;

Morelli, Dawn ;

Hall, MacLean ;

Bogle, Dilip ;

Yan, Lulu ;

Targan, Stephan ;

Solomon, Jolie ;

Nichol, Geoff ;

Yellin, Michael ;

Weber, Jeffrey S. .

CLINICAL CANCER RESEARCH, 2011, 17 (04) :896-906

[37] A phase I trial of cytotoxic T-lymphocyte precursor-oriented peptide vaccines for colorectal carcinoma patients [J].

Sato, Y ;

Maeda, Y ;

Shomura, H ;

Sasatomi, T ;

Takahashi, M ;

Une, Y ;

Kondo, M ;

Shinohara, T ;

Hida, N ;

Katagiri, K ;

Sato, K ;

Sato, M ;

Yamada, A ;

Yamana, H ;

Harada, M ;

Itoh, K ;

Todo, S .

BRITISH JOURNAL OF CANCER, 2004, 90 (07) :1334-1342

[38] Immunological evaluation of peptide vaccination for patients with gastric cancer based on pre-existing cellular response to peptide [J].

Sato, Y ;

Shomura, H ;

Maeda, Y ;

Mine, T ;

Une, Y ;

Akasaka, Y ;

Kondo, M ;

Takahashi, S ;

Shinohara, T ;

Katagiri, K ;

Sato, M ;

Okada, S ;

Matsui, K ;

Yamada, A ;

Yamana, H ;

Itoh, K ;

Todo, S .

CANCER SCIENCE, 2003, 94 (09) :802-808

[39] Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil derivative (TS-1) for advanced gastric or colorectal carcinoma patients [J].

Sato, Yuji ;

Fujiwara, Toshiyoshi ;

Mine, Takashi ;

Shomura, Hiroki ;

Homma, Shigenori ;

Maeda, Yoshiaki ;

Tokunaga, Naoyuki ;

Ikeda, Yoshihiro ;

Ishihara, Yuki ;

Yamada, Akira ;

Tanaka, Noriaki ;

Itoh, Kyogo ;

Harada, Mamoru ;

Todo, Satoru .

CANCER SCIENCE, 2007, 98 (07) :1113-1119

[40] Immunologic and clinical outcomes of a Randomized phase II trial of two multipeptide Vaccines for melanoma in the adjuvant setting [J].

Slingluff, Craig L., Jr. ;

Petroni, Gina R. ;

Chianese-Bullock, Kimberly A. ;

Smolkin, Mark E. ;

Hibbitts, Sarah ;

Murphy, Cheryl ;

Johansen, Naomi ;

Grosh, William W. ;

Yamshchikov, Galina V. ;

Neese, Patrice Y. ;

Patterson, James W. ;

Fink, Robyn ;

Rehm, Patrice K. .

CLINICAL CANCER RESEARCH, 2007, 13 (21) :6386-6395

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