Modelling of proteins in membranes

被引：49

作者：

Sperotto, Maria Maddalena

May, Sylvio

Baumgaertner, Artur ^{[1
]}

机构：

[1] Res Ctr Julich, Dept Solid State Res, Julich, Germany

[2] N Dakota State Univ, Dept Phys, Fargo, ND 58105 USA

[3] Tech Univ Denmark, Bioctr, DK-2800 Lyngby, Denmark

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2006年 / 141卷 / 1-2期

关键词：

dissipative particle dynamics; coarse-grain model; mesoscopic model; molecular dynamics; Monte Carlo; hydrophobic mismatch; tilting; phase transition; cooperative behavior; protein insertion; ion channel; Poisson-Boltzmann; lipid-protein interaction;

D O I：

10.1016/j.chemphyslip.2006.02.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review describes some recent theories and simulations of mesoscopic and microscopic models of lipid membranes with embedded or attached proteins. We summarize results supporting our understanding of phenomena for which the activities of proteins in membranes are expected to be significantly affected by the lipid environment. Theoretical predictions are pointed out, and compared to experimental findings, if available. Among others, the following phenomena are discussed: interactions of interfacially adsorbed peptides, pore-forming amphipathic peptides, adsorption of charged proteins onto oppositely charged lipid membranes, lipid-induced tilting of proteins embedded in lipid bilayers, protein-induced bilayer deformations, protein insertion and assembly, and lipid-controlled functioning of membrane proteins. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：2 / 29

页数：28

共 199 条

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