MicroRNA Silencing in Primates: Towards Development of Novel Therapeutics

被引：65

作者：

Petri, Andreas ^{[1
]}

Lindow, Morten ^{[1
]}

Kauppinen, Sakari ^{[1
,2
]}

机构：

[1] Santaris Pharma, DK-2970 Horsholm, Denmark

[2] Univ Copenhagen, Wilhelm Johannsen Ctr Funct Genome Res, Dept Cellular & Mol Med, Copenhagen, Denmark

来源：

CANCER RESEARCH | 2009年 / 69卷 / 02期

基金：

英国医学研究理事会;

关键词：

TUMOR-SUPPRESSOR NETWORK; IN-VIVO; ANTISENSE; RNA; LIVER; MICE;

D O I：

10.1158/0008-5472.CAN-08-2749

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNA) comprise an abundant class of small noncoding RNAs that act as important posttranscriptional regulators of gene expression. Accumulating evidence showing that aberrantly expressed miRNAs play important roles in human cancers underscores them as potential targets for therapeutic intervention. Recent reports on efficient miRNA silencing in rodents and nonhuman primates using high-affinity targeting by chemically modified antisense oligonucleotides highlight the utility of such compounds in the development of miRNA-based cancer therapeutics. [Cancer Res 2009;69(2):393-5]

引用

收藏

页码：393 / 395

页数：3

相关论文

共 23 条

[11] A microRNA polycistron as a potential human oncogene [J].

He, L ;

Thomson, JM ;

Hemann, MT ;

Hernando-Monge, E ;

Mu, D ;

Goodson, S ;

Powers, S ;

Cordon-Cardo, C ;

Lowe, SW ;

Hannon, GJ ;

Hammond, SM .

NATURE, 2005, 435 (7043) :828-833

[12] A microRNA component of the p53 tumour suppressor network [J].

He, Lin ;

He, Xingyue ;

Lim, Lee P. ;

De Stanchina, Elisa ;

Xuan, Zhenyu ;

Liang, Yu ;

Xue, Wen ;

Zender, Lars ;

Magnus, Jill ;

Ridzon, Dana ;

Jackson, Aimee L. ;

Linsley, Peter S. ;

Chen, Caifu ;

Lowe, Scott W. ;

Cleary, Michele A. ;

Hannon, Gregory J. .

NATURE, 2007, 447 (7148) :1130-U16

[13] The guardian's little helper: MicroRNAs in the p53 tumor suppressor network [J].

He, Xingyue ;

He, Lin ;

Hannon, Gregory J. .

CANCER RESEARCH, 2007, 67 (23) :11099-11101

[14] Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome [J].

Jopling, Catherine L. ;

Schuetz, Sylvia ;

Sarnow, Peter .

CELL HOST & MICROBE, 2008, 4 (01) :77-85

[15] Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA [J].

Jopling, CL ;

Yi, MK ;

Lancaster, AM ;

Lemon, SM ;

Sarnow, P .

SCIENCE, 2005, 309 (5740) :1577-1581

[16] Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides [J].

Juliano, Rudy ;

Alam, Md. Rowshon ;

Dixit, Vidula ;

Kang, Hyumin .

NUCLEIC ACIDS RESEARCH, 2008, 36 (12) :4158-4171

[17] The diverse functions of MicroRNAs in animal development and disease [J].

Kloosterman, Wigard P. ;

Plasterk, Ronald H. A. .

DEVELOPMENTAL CELL, 2006, 11 (04) :441-450

[18] Silencing of microRNAs in vivo with 'antagomirs' [J].

Krützfeldt, J ;

Rajewsky, N ;

Braich, R ;

Rajeev, KG ;

Tuschl, T ;

Manoharan, M ;

Stoffel, M .

NATURE, 2005, 438 (7068) :685-689

[19] Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets [J].

Lewis, BP ;

Burge, CB ;

Bartel, DP .

CELL, 2005, 120 (01) :15-20

[20]

Sage C Ie, 2007, EMBO J, V26, P3699