Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus

被引：42

作者：

Whittaker, E ^{[1
]}

Vereker, E ^{[1
]}

Lynch, MA ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Dept Physiol, Dublin 2, Ireland

来源：

BRAIN RESEARCH | 1999年 / 827卷 / 1-2期

关键词：

long-term potentiation; neuropeptide Y; c-Jun-activated protein kinase; dentate gyrus; glutamate release;

D O I：

10.1016/S0006-8993(99)01302-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of intracerebroventricular injection of neuropeptide Y (NPY) was assessed on LTP in dentate gyrus. We report that NPY attenuated LTP and inhibited KCI-induced glutamate release in synaptosomes prepared from dentate gyrus. Activity of the stress-activated kinase, c-Jun NH2-terminal kinase (JNK) in synaptosomes was increased by incubation with NPY or following intracerebroventricular injection. Activation of JNK might underlie the inhibitory effect of NPY on LTP. (C) 1999 Elsevier Science B.V. AU rights reserved.

引用

页码：229 / 233

页数：5

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