No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population

被引：10

作者：

Bagli, M ^{[1
]}

Papassotiropoulos, A ^{[1
]}

Schwab, SG ^{[1
]}

Jessen, F ^{[1
]}

Rao, ML ^{[1
]}

Maier, W ^{[1
]}

Heun, R ^{[1
]}

机构：

[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1999年 / 167卷 / 01期

关键词：

Alzheimer disease; presenilin-1; apolipoprotein E; polymorphism;

D O I：

10.1016/S0022-510X(99)00131-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A polymorphism in intron 8 of the presenilin-1 (PS-1) gene has been demonstrated to increase the risk for developing late-onset Alzheimer disease (AD). Conflicting results exist for the association between this intronic polymorphism and AD probably due to variations in the PS-1 gene among different ethnic groups. We investigated the genetic association between this intronic polymorphism in the PS-1 gene and AD in a homogenous group of German Caucasians. The control group consisted of healthy subjects and depressed patients. There were no significant differences in the distribution of the PS-1 genotypes and allele frequencies between AD patients and controls. Our data do not support an association between the intronic polymorphism of the PS-1 gene and AD and there was no interaction between the PS-1 genotype and apolipoprotein E epsilon 4 allele. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：34 / 36

页数：3

共 21 条

[21] Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease [J].

Wragg, M ;

Hutton, M ;

Talbot, C ;

Busfield, F ;

Han, SW ;

Lendon, C ;

Clark, RF ;

Morris, JC ;

Edwards, D ;

Goate, A ;

Pfeiffer, E ;

Crook, R ;

Prihar, G ;

Phillips, H ;

Baker, M ;

Hardy, J ;

Rossor, M ;

Houlden, H ;

Karran, E ;

Roberts, G ;

Craddock, N .

LANCET, 1996, 347 (9000) :509-512

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