5-HTTLPR genotype influences amygdala volume

被引:26
作者
Scherk, Harald [1 ,2 ]
Gruber, Oliver [2 ]
Menzel, Patrick [3 ]
Schneider-Axmann, Thomas [2 ]
Kemmer, Claudia [3 ]
Usher, Juliana [2 ]
Reith, Wolfgang [4 ]
Meyer, Jobst [5 ]
Falkai, Peter [2 ]
机构
[1] AMEOS Klinikum Osnabruck, D-49088 Osnabruck, Germany
[2] Univ Gottingen, Dept Psychiat & Psychotherapy, D-37075 Gottingen, Germany
[3] Saarland Univ Hosp, Dept Psychiat & Psychotherapy, Homburg, Germany
[4] Saarland Univ Hosp, Dept Neuroradiol, Homburg, Germany
[5] Univ Trier, Dept Neurobehav Genet, Grad Sch Psychobiol, Trier, Germany
关键词
serotonin; SLC6A4; 5-HTTLPR; MRI; amygdala; bipolar disorder; BIPOLAR AFFECTIVE-DISORDER; SEROTONIN TRANSPORTER; GENETIC-VARIATION; YOUNG-ADULTS; POLYMORPHISM; BRAIN; METAANALYSIS; MORPHOMETRY; ADOLESCENTS;
D O I
10.1007/s00406-008-0853-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Functional imaging studies in healthy individuals revealed an association between 5-HTTLPR genotype and neuronal activity in the amygdala. The aim of this study was firstly to investigate a possible overall impact of the 5-HTTLPR on amygdala volume in patients with bipolar disorder and healthy individuals and secondly to test a diagnosis specific influence of the 5-HTTLPR on amygdala volume. We performed a region of interest analysis of amygdala volume in 37 patients with bipolar I disorder and 37 healthy control subjects. The 5-HTTLPR genotype of each proband was determined and the subjects were separated according to 5-HTTLPR genotype and for statistical analyses the groups SS and SL were combined and compared with the group LL. This study shows that carriers of the short allele (SL or SS) of the 5-HTTLPR polymorphism exhibit a relatively increased volume of the right amygdala compared to homozygous L-allele carriers irrespective of diagnosis status. However, further analyses with the factors genotype and diagnosis were not able to reproduce this result. The present findings are consistent with the view that the 5-HTTLPR polymorphism might modulate neuronal size or number in the amygdala. It would be worthwhile investigating the relationship between serotonin transporter function and amygdala function and volume in further studies.
引用
收藏
页码:212 / 217
页数:6
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