Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

被引：588

作者：

Haniffa, Muzlifah ^{[1
,2
]}

Shin, Amanda ^{[2
]}

Bigley, Venetia ^{[1
]}

McGovern, Naomi ^{[1
]}

Teo, Pearline ^{[2
]}

See, Peter ^{[2
]}

Wasan, Pavandip Singh ^{[2
]}

Wang, Xiao-Nong ^{[1
]}

Malinarich, Frano ^{[2
]}

Malleret, Benoit ^{[2
]}

Larbi, Anis ^{[2
]}

Tan, Pearlie ^{[3
]}

Zhao, Helen ^{[2
]}

Poidinger, Michael ^{[2
]}

Pagan, Sarah ^{[1
]}

Cookson, Sharon ^{[1
]}

Dickinson, Rachel ^{[1
]}

Dimmick, Ian ^{[1
]}

Jarrett, Ruth F. ^{[4
]}

Renia, Laurent ^{[2
]}

Tam, John ^{[5
,6
]}

Song, Colin ^{[3
]}

Connolly, John ^{[2
]}

Chan, Jerry K. Y. ^{[6
,7
,8
]}

Gehring, Adam ^{[9
]}

Bertoletti, Antonio ^{[9
]}

Collin, Matthew ^{[1
]}

Ginhoux, Florent ^{[2
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] ASTAR, Singapore Immunol Network, Singapore 138648, Singapore

[3] Singapore Gen Hosp, Singapore 169608, Singapore

[4] Univ Glasgow, Ctr Virus Res, Glasgow G61 1QH, Lanark, Scotland

[5] Natl Univ Singapore Hosp, Singapore 119074, Singapore

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 119077, Singapore

[7] KK Womens & Childrens Hosp, Singapore 229989, Singapore

[8] Duke NUS Grad Med Sch, Singapore 169857, Singapore

[9] ASTAR, Singapore Inst Clin Sci, Singapore 117609, Singapore

来源：

IMMUNITY | 2012年 / 37卷 / 01期

基金：

英国惠康基金;

关键词：

EPIDERMAL LANGERHANS CELLS; IN-VIVO; T-CELLS; SUBSETS; RECEPTOR; EXPRESSION; RESIDENT; ANTIGEN; BLOOD; IDENTIFICATION;

D O I：

10.1016/j.immuni.2012.04.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the periphery is critical for the initiation of CD8(+) T cell responses. Several DC subsets are described in human tissues but migratory cross-presenting DCs have not been isolated, despite their potential importance in immunity to pathogens, vaccines, and tumors and tolerance to self. Here, we identified a CD141(hi) DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c(+) and CD14(+) tissue DCs and superior at cross-presenting soluble antigens. Cutaneous CD141(hi) DCs were closely related to blood CD141(+) DCs, and migratory counterparts were found among skin-draining lymph node DCs. Comparative transcriptomic analysis with mouse showed tissue DC subsets to be conserved between species and permitted close alignment of human and mouse DC subsets. These studies inform the rational design of targeted innmunotherapies and facilitate translation of mouse functional DC biology to the human setting.

引用

页码：60 / 73

页数：14

共 53 条

[1]

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].