α-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors

被引：21

作者：

Asso, Valentina ^{[1
]}

Ghilardi, Elisa ^{[1
]}

Bertini, Simone ^{[1
]}

Digiacomo, Maria ^{[1
]}

Granchi, Carlotta ^{[1
]}

Minutolo, Filippo ^{[1
]}

Rapposelli, Simona ^{[1
]}

Bortolato, Andrea ^{[2
]}

Moro, Stefano ^{[2
]}

Macchia, Marco ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Sci Farmaceut, I-56126 Pisa, Italy

[2] Univ Padua, Dipartimento Sci Farmaceut, Mol Modeling Sect, I-35131 Padua, Italy

来源：

CHEMMEDCHEM | 2008年 / 3卷 / 10期

关键词：

Alzheimer's disease; amino alcohols; BACE1; molecular modeling; inhibitors;

D O I：

10.1002/cmdc.200800162

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

(Figure Presented) Fast and healthy (molecular) weight loss! A relatively large BACE1 inhibitor containing a hydroxyethylamine aspartyl protease inhibitor motif was identified by high-throughput screening, and has inspired the design of new "lighter", biologically active derivatives, representing a promising new class anti-Alzheimer's drugs. © 2008 Wiley-VCH Verlag GmbH& Co. KGaA.

引用

页码：1530 / 1534

页数：5

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