Bacteria and Primary Biliary Cirrhosis

被引：74

作者：

Bogdanos, Dimitrios P. ^{[1
]}

Vergani, Diego ^{[1
]}

机构：

[1] Kings Coll Hosp, Kings Coll London, Sch Med, Inst Liver Studies, London SE5 9RS, England

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2009年 / 36卷 / 01期

关键词：

Autoimmunity; Autoimmune disease; Bile ducts; Cholestasis; Liver; Immunity; Tolerance; PYRUVATE-DEHYDROGENASE COMPLEX; HEPATITIS-C VIRUS; IMMUNOLOGICAL CROSS-REACTIVITY; AUTOIMMUNE LIVER-DISEASE; REGULATORY T-CELLS; PRIMARY SCLEROSING CHOLANGITIS; URINARY-TRACT-INFECTION; HEAT-SHOCK-PROTEIN; MOLECULAR MIMICRY; ANTIMITOCHONDRIAL ANTIBODIES;

D O I：

10.1007/s12016-008-8087-9

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Infectious agents have been postulated to play a pathogenic role in the loss of immunological tolerance and the induction of primary biliary cirrhosis, an immune-mediated cholestatic liver disease characterized by progressive destruction of the small intrahepatic bile ducts and subsequent cirrhosis and liver failure. This review discusses emerging issues implicating infectious agents such as Escherichia coli, mycobacteria, chlamydia, helicobacter species, lactobacilli, Novosphingobium aromaticivorans, and betaretroviruses in the pathogenesis of primary biliary cirrhosis. We also review the immunopathological mechanisms responsible for the induction of the disease with special emphasis on the role of molecular mimicry and microbial/self immunological cross-reactivity.

引用

页码：30 / 39

页数：10

共 97 条

[1] Primary biliary cirrhosis:: an infectious disease caused by Chlamydia pneumoniae? [J].

Abdulkarim, AS ;

Petrovic, LM ;

Kim, WR ;

Angulo, P ;

Lloyd, RV ;

Lindor, KD .

JOURNAL OF HEPATOLOGY, 2004, 40 (03) :380-384

[2]

Abu-Mouch Saif, 2003, Clin Dev Immunol, V10, P127

[3]

Anand AC, 1996, EUR J GASTROEN HEPAT, V8, P663

[4] NATURE OF THE MITOCHONDRIAL ANTIGENS OF PRIMARY BILIARY-CIRRHOSIS AND THEIR POSSIBLE RELATIONSHIPS TO THE ETIOLOGY OF THE DISEASE [J].

BAUM, H .

SEMINARS IN LIVER DISEASE, 1989, 9 (02) :117-123

[5]

Baum H, 1981, Semin Liver Dis, V1, P309, DOI 10.1055/s-2008-1040734

[6] MITOCHONDRIAL ANTIGENS, MOLECULAR MIMICRY AND AUTOIMMUNE-DISEASE [J].

BAUM, H .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1995, 1271 (01) :111-121

[7] Antibodies to Clp protease in primary biliary cirrhosis: possible role of a mimicking T-cell epitope [J].

Baum, H ;

Bogdanos, DP ;

Vergani, D .

JOURNAL OF HEPATOLOGY, 2001, 34 (05) :785-787

[8] Borrelia Burgdorferi: a new self-mimicking trigger in primary biliary cirrhosis [J].

Bogdanos, D. -P. ;

Koutsoumpas, A. ;

Baum, H. ;

Vergani, D. .

DIGESTIVE AND LIVER DISEASE, 2006, 38 (10) :781-782

[9] Viral/self-mimicry and immunological cross-reactivity as a trigger of hepatic C virus associated autoimmune diabetes [J].

Bogdanos, Dimitrios-Petrou ;

Rigopoulou, Eirini I. .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 77 (01) :155-156

[10]

Bogdanos Dimitrios-Petrou, 2003, Clin Liver Dis, V7, P759, DOI 10.1016/S1089-3261(03)00104-1

← 1 2 3 4 5 6 7 8 9 10 →