Renal effects of an angiotensin II antagonist in stroke-prone spontaneously hypertensive rat

被引：3

作者：

Yo, Y ^{[1
]}

Moriguchi, A ^{[1
]}

Higaki, J ^{[1
]}

Nagano, M ^{[1
]}

Nakano, N ^{[1
]}

Kamide, K ^{[1
]}

Yu, H ^{[1
]}

Mikami, H ^{[1
]}

Ogihara, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT GERIATR MED,SUITA,OSAKA 565,JAPAN

来源：

NEPHRON | 1997年 / 76卷 / 04期

关键词：

angiotensin II type 1 receptor antagonist; HR; 720; hypertension; urinary protein; glomerular sclerosis;

D O I：

10.1159/000190230

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the renal effects of the new angiotensin II type 1 (AT1) receptor antagonist, HR 720, in the stroke-prone spontaneously hypertensive rat. Rats were treated with either vehicle, HR 720, MK-954 (a selective ATL receptor antagonist) or enalapril for 6 weeks. Blood pressure was decreased to a similar extent by HR 720, MK-954 and enalapril (203 +/- 4, 202 +/- 5 and 190 +/- 4 vs. 247 +/- 4 mm Hg for control). Urinary protein secretion was also decreased (5.2 +/- 0.3, 5.3 +/- 0.2 and 5.5 +/- 0.6 vs. 25.2 +/- 4.6 mg/100 g/24 h). The glomerular hypertensive change was improved in each drug-treated group (2.0 +/- 0.2, 3.3 +/- 0.3 and 1.6 +/- 0.1 vs. 17.6 +/- 1.5%; p < 0.0001). These results show that, in addition to its antihypertensive effect, HR 720 has a beneficial effect on renal function.

引用

页码：466 / 471

页数：6

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